| 主权项 |
1. A compound represented by Formula (1) below or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, tautomer, enantiomer, or pharmaceutically acceptable diastereomer thereof: wherein R1 and R2 are each independently hydrogen, a halogen, substituted or unsubstituted C1-C20 alkoxy, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C4-C10 aryl, substituted or unsubstituted C4-C10 aryloxy, substituted or unsubstituted C2-C10 heteroaryl, —NO2, —NR′1R′2, —NR′1 (CO (O)R′2), —NR′1 (C (O)NR′1R′2), —CO (O)R′1, —C(O)NR′1R′2, —CN, —SO (O)R′1, —SO (O)NR′1R′2, —NR′1 (SO (O)R′2), or —CSNR′1R′2, or R1 and R2 form a ring structure of substituted or unsubstituted C4-C10 aryl through coupling or a ring structure of substituted or unsubstituted C2-C10 heteroaryl, where R′1 and R′2 are each independently hydrogen, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C4-C10 aryl, substituted or unsubstituted C4-C10 aryloxy, substituted or unsubstituted C1-C8 heteroaryl, substituted or unsubstituted —(CR″1R″2)m′—C4-C10 aryl, or substituted or unsubstituted NR″1R″2; where R″1 and R″2 are each independently hydrogen, or C1-C3 alkyl, or R″1 and R″2 form a ring structure of substituted or unsubstituted C4-C10 aryl through coupling; R3, R4, R5, and R6 are each independently hydrogen, a halogen, substituted or unsubstituted C1-C9 alkyl, substituted or unsubstituted C2-C20 alkene, substituted or unsubstituted C1-C20 alkoxy, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C2-C8 heterocycloalkyl, substituted or unsubstituted C4-C10 aryl, substituted or unsubstituted C4-C10 aryloxy, substituted or unsubstituted C1-C10 heteroaryl, substituted or unsubstituted —(CR′5R′6)m—C4-C10 aryl, substituted or unsubstituted —(CR′5R′6)m—C4-C10 aryloxy, substituted or unsubstituted —(CR′5R′6)m—C4-C10 heteroaryl, substituted or unsubstituted —(CR′5R′6)m—C4-C10 heterocycloalkyl, substituted or unsubstituted —(CR′5R′6)m—NR′3R′4, substituted or unsubstituted —(CR′5R′6)m—OR′3, —CO (O)R′3, —CONR′3R′4, —NR′3R′4, —NR′3 (C (O)R′4), —SO (O)R′3, —SO (O)NR′3R′4, —NR′3 (SO (O)R′4), —CSNR′3R′4, —CH2A when the compound of Formula (1) is “A”, or −A when the compound of Formula (1) is “A”; where R′3 and R′4 are each independently hydrogen, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C4-C10 aryl, substituted or unsubstituted —(CH2)m—C4-C10 aryl, substituted or unsubstituted —(CH2)m—C4-C10 aryloxy, or —CO (O)R″3, or R′3 and R′4 form a ring structure of substituted or unsubstituted C4-C10 heterocycloalkyl through coupling or substituted or unsubstituted C4-C10 heteroaryl; R′5 and R′6 are each independently hydrogen or C1-C3 alkyl; and R″3 is C1-C6 alkyl, wherein the substituted group is at least one selected from the group consisting of hydroxy, a halogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 alkoxy, C1-C10 alkoxycarbonyl, C3-C8 cycloalkyl, C2-C8 heterocycloalkyl, C4-C10 aryl, and C2-C10 heteroaryl; R3 and R4 are each independently not C4-C10 aryl, R4 and R6 are each independently not C4-C10 aryl, R4 is not hydrogen, methyl, orwhen R3 is defined as above, and R5 is not phenyl;
m and m′ are each independently a natural number of 1 to 4; the heteroatom is at least one selected from N, O, and S; X1, X2, X3 and X4 are each independently CH or N; and n is 0 or 1 and, when n is 0, neighboring carbon atoms thereof form a ring structure through direct coupling. |
