发明名称 |
Local anesthetic compounds and uses |
摘要 |
Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.
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申请公布号 |
US6576791(B1) |
申请公布日期 |
2003.06.10 |
申请号 |
US20000647802 |
申请日期 |
2000.10.03 |
申请人 |
THERAVANCE, INC. |
发明人 |
AXT SABINE M.;CHURCH TIMOTHY J.;HRUZEWICZ WITOLD N.;JACOBSEN JOHN R.;JENKINS THOMAS E.;JI YU-HUA;JUDICE J. KEVIN |
分类号 |
C07D241/12;A61K31/16;A61K31/33;A61K31/395;A61K31/445;A61P23/02;A61P25/04;C07C233/04;C07C237/04;C07C237/34;C07D211/60;C07D211/62;C07D255/02;C07D273/00;C07D273/08;(IPC1-7):C07C233/05 |
主分类号 |
C07D241/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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