| 摘要 |
The present invention relates to new, efficient processes for the preparation of 5-(2-oxazolylalkylthio)-2-azacycloalkanoylaminothiazole compounds of formula Ior a pharmaceutically acceptable salt thereof, wherein:R is alkyl, aryl or heteroaryl;R<1>, R<2>, R<3>, R<4 >and R<5 >are each independently hydrogen, alkyl, aryl or heteroaryl;R<6 >and R<7 >are each independently hydrogen, alkyl, aryl, heteroaryl, halogen, hydroxy or alkoxy;R<8 >is hydrogen, alkyl, aryl, heteroaryl, CONR<9>R<10>, COR<11 >or COOR<12>;R<9>, R<10>, R<11 >and R<12 >are each independently hydrogen, alkyl or aryl;m equals 0 to 5; andn equals 0 to 5,which are novel, potent inhibitors of cyclin dependent kinases (cdks). The present invention further concerns new key intermediate compounds, a quaternary ammonium salt of formula III' and a 2-oxazolylalkyl derivative of formula IX. |
