Mouse unable to express functional alpha-4 integrin protein, and methods for assaying compounds or agents for alpha-4 integrin protein antagonist activity and a genetic marker for evaluating efficacy of modulators of signaling activity of a VLA-4 receptor

摘要

Provided herein is a mouse that is unable to express functional alpha-4 integrin protein, and methods for assaying agents for alpha-4 integrin antagonist activity, as well genetic markers for analyzing the efficacy of VLA-4 modulators, and particularly antagonists.