发明名称 |
Microprecipitation method for preparing submicron suspensions |
摘要 |
The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of (i) dissolving the organic compound in the water-miscible first solvent to form a solution, (ii) mixing the solution with the second solvent to define a pre-suspension; and (iii) adding energy to the pre-suspension to form particles having an average effective particle size of 400 nm to 2 microns.
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申请公布号 |
US6607784(B2) |
申请公布日期 |
2003.08.19 |
申请号 |
US20010874799 |
申请日期 |
2001.06.05 |
申请人 |
BAXTER INTERNATIONAL INC. |
发明人 |
KIPP JAMES E.;WONG JOSEPH CHUNG TAK;DOTY MARK J.;REBBECK CHRISTINE L. |
分类号 |
A61K;A61K9/10;A61K9/14;A61K9/16;A61K31/495;A61K31/496;(IPC1-7):B01J13/02;B32B15/02 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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