Peptides with growth inhibitory action

摘要

Peptides and peptide compositions are identified which inhibit the growth of abnormal cells. In one embodiment, the peptides are useful for inhibiting the growth of cells dependent on autocrine activation of the PDGF receptor. Such peptides may be used in the treatment of cell proliferative disorders including cancer, fibrotic disorders, myeloproliferative diseases and blood vessel proliferative (angiogenic) disorders characterized by inappropriate PDGF receptor activity. A biomedical device is further disclosed which has associated with it a peptide or peptide composition according to the present invention.