NOVEL IMIDAZOLIDINE-2,4-DIONE DERIVATIVES

摘要

Imidazolidine-2,4-dione derivatives of formula (I):;;The compounds have anti-proliferative activity and are useful for treating pathological states and diseases linked to an abnormal cell proliferation such as cancer.

主权项

1. A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein:
R1 is a —CF3 group or a halogen atom;each R2 is individually a (C1-C6)alkyl group or the two R2 groups together form a (C3-C6)cycloalkyl group;X is CH or N;each R3 is individually a hydrogen atom or a (C1-C6)alkyl group or the two R3 groups together form a (C3-C6)cycloalkyl group;R4 is a (C1-C6)alkyl group; andR5 is a —CF3 group or a halogen atom.