发明名称 |
SYNTHESIS OF N,N-DIMETHYL-3-(4-METHYL) BENZOYL PROPIONAMIDE, A KEY INTERMEDIATE OF ZOLPIDEM |
摘要 |
<p>The present invention relates to an improved and industrially advantageous process for the preparation of N,N-dimethyl-3-(4-methyl)benzoyl propionamide of Formula I, which is a key intermediate in the synthesis of zolpidem hemitartrate, a non-benzodiazepine hypnotic agent. The process includes reacting 3-(4-methyl)-benzoyl propionic acid of Formula IV, with alkyl chloroformate or pivaloyl chloride to get a mixed anhydride of Formula V; and reacting the mixed anhydride of Formula V with dimethylamine of Formula VI to get the N,N-dimethyl-3-(4-methyl)benzoyl propionamide of Formula I.</p> |
申请公布号 |
EP1370515(A2) |
申请公布日期 |
2003.12.17 |
申请号 |
EP20010963296 |
申请日期 |
2001.08.28 |
申请人 |
RANBAXY LABORATORIES, LTD. |
发明人 |
KUMAR, YATENDRA;PRASAD, MOHAN;NATH, ASOK |
分类号 |
C07C231/02;C07C235/78;C07D471/04;(IPC1-7):C07C231/02;C07C233/05 |
主分类号 |
C07C231/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|