Natural tissue scaffolds as tissue fillers

摘要

Tissue fillers derived from decellularized tissues are provided. The tissue fillers can include acellular tissue matrices that have reduced inflammatory responses when implanted in a body. Also provided are methods of making and therapeutic uses for the tissue fillers.

主权项

1. A tissue filler, comprising:
an acellular tissue matrix having a stable three-dimensional structure, having the ability to maintain the same shape, size, and sponge property after being implanted for two weeks as was observed prior to implantation; and at least one of exogenous hyaluronic acid (HA) and exogenous decorin on a surface of the acellular tissue matrix at a concentration which reduces an inflammatory response or fibrosis when the tissue filler is implanted in a body as compared to the same tissue filler not comprising hyaluronic acid or decorin.