发明名称 |
In vitro-fremgangsmåde til fremstilling af en homolog hjerteklap- eller karprotese |
摘要 |
In vitro production of a homologous heart valve involves: (i) colonizing a biodegradable carrier with homologous fibroblasts and/or myofibroblasts so as to give a connective tissue matrix; (ii) colonizing the matrix with endothelial cells; (iii) introducing the matrix into a pulsating flow chamber (e.g. in a bioreactor) where it is subjected to a (dis)continuous flow rate. An Independent claim is also included for a homologous heart valve with a connective tissue inner core covered with a layer of endothelial cells, the core having a collagen density of 43-55%, based on the matrix. |
申请公布号 |
DK1077072(T3) |
申请公布日期 |
2004.03.22 |
申请号 |
DK20000108986T |
申请日期 |
2000.04.27 |
申请人 |
SYMETIS AG |
发明人 |
HOERSTRUP, SIMON PHILIPP;ZUEND, GREGOR |
分类号 |
A61F2/24;A61L27/18;A61L27/38;A61L27/50;C12N5/08;(IPC1-7):A61L27/38 |
主分类号 |
A61F2/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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