PEPTIDE ANALOGS AND MIMETICS SUITABLE FOR IN VIVO USE IN THE TREATMENT OF DISEASES ASSOCIATED WITH ABNORMAL PROTEIN FOLDING INTO AMYLOID, AMYLOID-LIKE DEPOSITS OR beta-SHEET RICH PATHOLOGICAL PRECURSOR THEREOF.

摘要

The present invention is an inhibitory peptide capable of inhibiting beta pleated sheet formation in amyloid beta-peptide. The inhibitory peptide is a betasheet breaker peptide analog designed by chemical modification of beta sheet breaker peptide capable of inhibiting beta pleated sheet formation in amyloid beta-peptide. The present invention also includes an inhibitory peptide capable of inhibiting conformational changes in prion PrP protein associated with amyloidosis. The inhibitory peptide being a betasheet breaker peptide analog designed by chemical modification of a betasheet breaker peptide capable of inhibiting the conformational changes in prior PrP protein associated with amyloidosis. In addition, the present invention includes a peptide mimetic with the structure PMiAbeta5. In another embodiment, the peptide mimetic has the structure PMiPrP13. In yet another embodiment, the peptide mimetic has the structure PMiPrP5.