| 发明名称 |
BACKGROUND OF THE INVENTION |
| 摘要 |
This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABA<SUB>A </SUB>receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABA<SUB>A </SUB>receptors in tissue sections. |
| 申请公布号 |
PL366243(A1) |
申请公布日期 |
2005.01.24 |
| 申请号 |
PL20010366243 |
申请日期 |
2001.12.21 |
| 申请人 |
NEUROGEN CORP.;PFIZER,INC. |
发明人 |
LI GUIYING;PETERSON JOHN M.;ALBAUGH PAMELA;CURRIE KEVIN S.;CAI GUOLIN;GUSTAVSON LINDA M.;LEE KYUNGAE;HUTCHISON ALAN;SINGH VINOD;MAYNARD GEORGE D.;YUAN JUN;LING HONG XIE;GHOSH MANUKA;LIU NIAN;LUKE GEORGE P.;MITCHELL SCOTT;ALLEN MARTIN PATRICK;LIRAS SPIROS |
| 分类号 |
A61K31/415;A61K31/4184;A61K31/4196;A61K31/422;A61K31/4245;A61K31/435;A61K31/437;A61K31/438;A61K31/4439;A61K31/454;A61K31/506;A61K31/5377;A61K31/541;A61K31/55;A61P25/00;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;C07D233/20;C07D233/54;C07D401/04;C07D401/14;C07D403/04;C07D403/06;C07D403/14;C07D405/04;C07D405/14;C07D409/14;C07D413/06;C07D413/14;C07D417/04;C07D417/06;C07D417/14;C07D471/04;C07D473/00;C07D491/08;C07D491/10;C07D491/113 |
主分类号 |
A61K31/415 |
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