| 摘要 |
FIELD: organic synthesis. ^ SUBSTANCE: invention claims a method for preparing glutamic acid derivatives having general formula (7): in particular such as monatin: (radicals in the formulas are specified in description), for use as sweeteners or intermediates for production of drugs and the like. A method for preparing intermediates used in above method, including preparation of novel intermediates, is also claimed. Method of preparing optically active monatin and relevant intermediates also includes preparation of novel intermediates. More specifically, a method for preparing glutamic acid derivatives or salts thereof comprises preparation of a ketoglutaric acid derivative as precursor of desired glutamic acid derivative via aldol cross-condensation of a pyruvic acid derivative with oxaloacetic acid or pyruvic acid and, if necessary, decarboxylation of condensation product and replacement of carbonyl group of ketoglutaric acid derivative by amino group. ^ EFFECT: expanded synthetic possibilities in amino acid derivatives class. ^ 24 cl, 26 ex |
