| 摘要 |
SUBSTITUTED CYCLOBUTYLAMINE DERIVATIVESB WITH A NOVEL STRUCTURE REPRESENTED BY THE FOLLOWING FORMULA (I), WHEREIN R1 TO R4 AND Q EACH REPRESENTS A SPECIFIC SUBSTITUENT AND, IN PARTICULAR, Q REPRESENTS A QUINOLONE DERIVATIVE HAVING A SPECIFIC STRUCTURE. THESE DERIVATIVES ARE USEFUL AS ANTIBACTERIAL COMPOUNDS WHICH HAVE EXCELLENT ANTIBACTERIAL ACTIVITY AGAINST A WIDE SCOPE OF BACTERIA INCLUDING GRAM-NEGATIVE AND GRAM-POSITIVE BACTERIA, EXERT POTENT ANTIBACTERIAL ACTIVITY PARTICULARLY AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) STRAINS, PENICILLIN-RESISTANT PNEUMOCOCCUS STRAINS AND QUINOLONE-RESISTANT BACTERIA, AND ARE ALSO POSSESSED OF BOTH EXCELLENT PHARMACOKINETICS AND HIGH SAFETY.
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