GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis

摘要

The present disclosure generally provides compositions and methods for producing medicaments for eliciting an immune response against Neisseria spp. bacteria in a subject, particularly against a Neisseria meningitidis serogroup B strain. In particular, the disclosure relates to a composition comprising isolated antigenic vesicles prepared from a Neisseria species bacterium, wherein the bacterium is genetically modified to overexpress a GNA1870 polypeptide so as to produce a level of the GNA1870 polypeptide sufficient to provide for production of a vesicle that, when administered to a subject, elicits anti-GNA1870 antibodies.