发明名称 |
FORMULATION OF A MIXTURE OF FREE-B-RING FLAVONOIDS AND FLAVANS AS A THERAPEUTIC AGENT |
摘要 |
The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds --Free-B-ring flavonoids and flavans-- for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier.; This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse. |
申请公布号 |
HK1073247(A1) |
申请公布日期 |
2010.03.19 |
申请号 |
HK20050105928 |
申请日期 |
2005.07.12 |
申请人 |
UNIGEN PHARMACEUTICALS, INC. |
发明人 |
JIA, QI |
分类号 |
A61K31/353;A01N31/08;A61K;A61K31/05;A61K31/35;A61K31/352;A61K31/7048;A61K36/00;A61K36/18;A61K36/47;A61P3/04;A61P3/10;A61P9/00;A61P9/10;A61P11/00;A61P17/00;A61P17/02;A61P17/06;A61P19/02;A61P25/00;A61P25/04;A61P25/06;A61P25/28;A61P29/00;A61P31/04;A61P31/10;A61P31/12;A61P35/00;A61P37/02;A61P43/00 |
主分类号 |
A61K31/353 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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