Lipids and Lipid Compositions for the Delivery of Active Agents

摘要

This invention provides for a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R3, n, p, L1 and L2 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.;

主权项

1. A compound, or salt thereof, of formula (I): n is 0, 1, 2, 3 or 4; p is 0, 1, 2, 3, 4, 5, 6, 7 or 8; L1 is —O— or a bond; L2 is —OC(O)— or —C(O)O—; R1 is selected from: v 0, 1, 2, 3 or 4; w is 0, 1, 2, or 3; Cyl is 5-7 membered nitrogen containing heterocycle optionally substituted with one or two alkyl groups; Ar is an aryl group, optionally substituted with C1-8 alkly amino group; R and R′ are each, independently, hydrogen or C1-8 alkyl; and R2 is selected from C6-20 alkyl optionally substituted with a hydroxyl, C15-19 alkenyl, C1-12alkyl-OC(O)—C5-20alkyl, C1-12alkyl-C(O)O—C5-20alkyl and R3 is selected from: C4-22 alkyl, C12-22 alkenyl,