发明名称 ANTIBIOTIC COMPOUNDS THAT INHIBIT BACTERIAL PROTEIN SYNTHESIS
摘要 An aminoacylation/translation (AIT) system based on the protein synthesis system from the pathogen Pseudomonas aeruginosa, was used to screen chemical compounds for identifying inhibitors of protein synthesis. This system includes elongation factors: EF-Tu, EF-Ts and EF-G, aminoacyl tRNA synthetase (aaRS) specific for phenylalanine, PheRS, and ribosomes isolated from cultures of Pseudomonas aeruginosa. Compounds identified using this assay have been shown to contain broad spectrum activity against both Gram+ and Gram− pathogens. Methods of using the identified compounds, as well as derivatives and analogues of these compounds, as antimicrobial agents against bacterial infections are described.
申请公布号 US2016374997(A1) 申请公布日期 2016.12.29
申请号 US201615196225 申请日期 2016.06.29
申请人 The Board of Regents of The University of Texas System 发明人 Bullard James M.;Hu Yanmei;Palmer Stephanie O.
分类号 A61K31/433;A61K31/381;A61K31/426 主分类号 A61K31/433
代理机构 代理人
主权项
地址 Austin TX US