MICROARRAY FOR DELIVERY OF THERAPEUTIC AGENT, METHODS OF USE, AND METHODS OF MAKING

摘要

Devices and methods for manufacturing and using microstructure arrays are described. In the methods, formulation is introduced into cavities of a microprojection array mold by means that include a vacuum to achieve a more efficient and uniform filling of the cavities and/or reduce bubble formation in the cavities.

主权项

1. A method of making an array of microstructures comprising:
(a) dissolving or suspending at least one therapeutic agent in a first solvent to form a therapeutic agent solution or suspension; (b) dissolving at least one polymer in a second solvent to form a polymer matrix solution or suspension; (c) mixing the therapeutic agent solution or suspension and the polymer solution or suspension to form a polymer matrix solution or suspension; (d) applying a low vacuum to a mold having an array of microstructure cavities; (e) dispensing the polymer matrix solution or suspension on the mold; (f) filling the microstructure cavities in the mold; (g) drying the solution or suspension to form the array of microstructures.