3,4-DIHYDROPYRIDONES THEIR PRODUCTION AND THEIR MEDICINAL USE

摘要

1389505 1-Amino-2 carboxy-6-keto-tetrahydro pyridine derivatives BAYER AG 30 Aug 1973 [31 Aug 1972] 40848/73 Heading C2C Novel compounds of Formula I in which R1 is a hydrogen atom, a straight- or branched-chain alkyl radical, or a group -CO.O.R1, in which R1 is a radical consisting of a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon chain otpionally interrupted by one or two oxygen atoms; R2 is a saturated or unsaturated, straight-chain, branched or cyclic hydrocarbon radical, an aryl radical optionally carrying up to 3 identical or different substituents selected from alkyl, alkoxy, halogen, nitro, nitrile trifluoromethyl, carbalkoxy and SO n Alkyl (n=0, 1 or 2) radicals, or a naphthyl, quinolyl, isoquinolyl, pyridyl, pyrimidyl, thenyl, furyl or pyridyl radical optionally carrying one or more substituents selected from alkyl, alkoxy and halogen radicals; and R3 is a radical consisting of a straight or branched hydrocarbon chain optionally interrupted by one or two oxygen atoms and optionally containing one or more double or triple bonds are prepared by reacting compounds of formulae wherein R is alkyl alkenyl or alkynyl. Pharmaceutical compositions in conventional forms for oral, perlingual, topical or parenteral administration having antihypertensive, coronary antifibrillation and cholesterol lowering activity comprises an above novel compound and a carrier or diluent. The invention also includes treating non human animals with the above compounds or compositions.