SUBSTITUTED BENZOFURAN DERIVATIVES AS NOVEL ANTIMYCOBACTERIAL AGENTS

摘要

Novel bacterial inhibitors comprising benzofuran derivatives, and methods of bacterial inhibition using the inhibitors are disclosed. The inhibitors may inhibit, for example, mycobacteria, including M. tuberculosis, by inhibition of the Pksl3 enzyme. The inhibitors cmat exhibit potent whole cell and in vivo efficacy against M. tuberculosis.