| 摘要 |
<p>New compounds of the formula WHEREIN Ar is selected from the group consisting of phenylethyl, furyl, methylfuryl, thienyl, pyrrolyl, naphthyl, hydroxynaphthyl, and phenyl substituted by at least one member selected from the group consisting of halogen, hydroxyl, cyano, trifluoromethyl, akyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms, carbamoyl, amino of the formula -NR'R'', alkoxycarbonyl of the formula -CO-OR' wherein R'and R''are each alkyl of 1-4 carbon atoms, and alkylenedioxy of the formula -O-R '''-O- wherein R''' is alkylene of 1-4 carbon atoms, provided that said substituted phenyl is not 3,4-di-methoxyphenyl, and the addition salts thereof with the cation of an organic or inorganic base inhibit the enzyme activities of tyrosine hydroxylase and dopamine beta -hydroxylase and are useful chemotherapeutic agents in the treatment of essential hypertension.</p> |
