| 摘要 |
1464242 Benzofurans SMITHKLINE CORP 13 March 1975 [18 April 1974 17 Oct 1974] 10414/75 Heading C2C Novel compounds of Formula I or a pharmaceutically acceptable acid addition salt thereof, in which: R 1 is phenyl, halophenyl, dihalophenyl, trihalophenyl, lower alkylphenyl, di-lower alkylphenyl, tri-lower alkylphenyl, lower alkoxyphenyl, di-lower alkoxyphenyl, tri-lower alkoxyphenyl, lower alkyl-di-lower alkoxyphenyl or lower alkoxy-di-lower alkylphenyl; R 2 is hydrogen, halo, lower alkyl, lower alkoxy, nitro or trifluoromethyl; R 3 is a group of Formula A R 4 is hydrogen, methyl, ethyl or propyl and R 5 is methyl, ethyl or propyl or R 4 and R 5 together with the nitrogen atom to which they are attached form a pyrrolidine, piperidine, N-(lower alkyl)piperazine, morpholine or perhydroazepine ring; R 6 is hydrogen or hydroxy; m is 0 or 1 when R 6 is hydrogen and 1 when R 6 is hydroxy; n is 0 or 1; and Z is oxygen or sulphur are prepared by one of the following reaction schemes wherein R 1 , R 2 , R 4 , R 5 and n have the above significance and p is 2 or 3, X and Y are halogen, R 1 <SP>1</SP> is phenyl, mono-, di- or trihalo-phenyl or mono-, di- or tri-alkyl-phenyl. The benzothiophenes are similarly prepared by schemes analogous to reaction schemes 1 and 2 above. Pharmaceutical compositions in conventional forms for oral or parenteral administration and having vaso-dilatory activity comprise an above novel compound and a carrier or diluent. |
