| 摘要 |
<p>3-Fluoro-D-analine is prepared by an asymmetric synthesis wherein fluoroacetaldehyde is reacted with D-optically active amine, such as D- alpha -methylbenzylamine to form the corresponding acetaldimine, which is reacted with hydrogen cyanide to form D-2-(D- alpha -methylbenzylamino)-3-fluoropropionitrile, followed by hydrolysis of the nitrile and hydrogenolysis of the methylbenzyl group. Other D-optically active amines such as R(D)-phenyl-glycine and 1-amino-(S)-2-[(R)-1-hydroxyethyl]indoline may be employed in the above process in place of the D- alpha -methyl-benzyl amine. The 3-fluoro-D-alanine thus obtained is a potent antibacterial agent.</p> |
