| 摘要 |
<p>Heterocyclic bases such as quinolines, isoquinolines, benzoquinolines and phenanthridine react with indole and carboxamides in the presence of phosphorus oxychloride to provide indolylimidoylheterocyclic derivatives. Derivatives incorporating a dihydroquinoline, dihydroisoquinoline or dihydrobenzoquinoline moiety can be reduced to provide corresponding tetrahydro analogs. Typical examples of indolyl derivatives are 1,2-dihydro-6-methoxy-2-(5-methoxy-3-indolyl)-1-(5-methyl-1-pyrrolin-2 -yl)quinoline and 1-(5,5-dimethyl-1-pyrrolin-2-yl)-1,2,3,4-tetrahydro-6-methoxy-2-(5-met hoxy-3-indolyl)quinoline. The indolyl derivatives are useful as diuretic and antithrombogenic agents.</p> |
