| 发明名称 |
WERKWIJZE VOOR DE BEREIDING VAN NIEUWE 3-HETEROTHIOMETHYLCEFALOSPORAANZURE ESTERS. |
| 摘要 |
<p>This invention relates to the preparation of 3-heterothiomethyl cephalosporanic acid esters of the formula <IMAGE> by treating a 3-methylene cephalosporin of the formula <IMAGE> with a compound of the formula HETERO-S-S-hetero or X-S-hetero IN THE PRESENCE OF A BASE WHEREIN R is a readily removable ester group, R1 is in the alpha -configuration and is hydrogen or methoxy, and X is a leaving group. The resulting 3-heterothio cephalosporin esters are treated according to known methods to remove the ester protecting group and yield the corresponding free acids which have antibacterial activity.</p> |
| 申请公布号 |
NL7712900(A) |
申请公布日期 |
1978.06.12 |
| 申请号 |
NL19770012900 |
申请日期 |
1977.11.23 |
| 申请人 |
E.R. SQUIBB & SONS, INC. TE PRINCETON, NEW JERSEY, VER.ST.V.AM. |
发明人 |
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| 分类号 |
C07D;C07D501/02;C07D501/04;C07D501/36;C07D501/57;C07D501/60;(IPC1-7):07D501/60 |
主分类号 |
C07D |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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