| 摘要 |
Racemic and optically active compounds of the formula <IMAGE> wherein R1 is -COOR6, where R6 is hydrogen or alkyl of 1 to 4 carbon atoms; -OCO-R9 or -NH-CO-R9, where R9 is alkyl of 1 to 6 carbon atoms, phenyl (alkyl of 1 to 4 carbon atoms) or phenyl; -Q-CO-NR7R8, where Q is a single bond, oxygen, -NH-, -CH2- or -CH2-NH-, and R7 and R8 are hydrogen, lower alkyl or, taken together with the nitrogen, pyrrolidino, piperidino or morpholino; cyano-phenyl; carboxylphenyl; cyano-phenoxy; or carboxyl-phenoxy; R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkanoyl of 2 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms, amino, nitro or, together with R1, 3,4-methylenedioxy; R3 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or, together with R2 in the ortho-position, -CH=CH-CH=CH- or -(CH2)n- where n is an integer from 3 to 5; R4 is hydrogen or alkyl of 1 to 3 carbon atoms; and R5 is alkyl of 1 to 3 carbon atoms or, together with R4, -(CH2)p-, where p is an integer from 4 to 6; AND PHYSIOLOGICALLY COMPATIBLE ACID ADDITION SALTS THEREOF. The compounds as well as their salts are useful as adrenolytics and hypotensives.
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