COMBINATION, KIT AND METHOD OF REDUCING INTRAOCULAR PRESSURE

摘要

The invention is directed to a combination or a kit for reducing intraocular pressure (IOP) in an eye of a subject, comprising a prostaglandin analog and an adenosine receptor Aagonist, and to a method of reducing intraocular pressure in a subject using such combination or kit, wherein the prostaglandin analog is latanoprost marketed under the brand Xalatan™, and the adenosine receptor Aagonist is a compound ((2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl nitrate of formulaor a pharmaceutically acceptable salt thereof.