摘要 |
Novel compounds of structural formula (I), wherein R, T, U, V, W, X, Y and Z are disclosed in the claims, are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension. |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
ANAND Rajan;APGAR James, M.;BIFTU Tesfaye;CHEN Ping;CHU Lin;COLANDREA Vincent, J.;DONG Guizhen;DROPINSKI James, F.;FENG Danqing;HICKS Jacqueline, D.;JIANG Jinlong;KIM Alexander, J.;LEAVITT Kenneth, J.;LI Bing;QIAN Xiaoxia;SEBHAT Iyassu;WEI Lan;WILKENING Robert, R.;WU Zhicai |