发明名称 |
A SEROTYPE CROSS-REACTIVE, DENGUE NEUTRALIZING ANTIBODY AND USES THEREOF |
摘要 |
Disclosed are isolated antibodies, or antigen binding fragments thereof, that bind to dengue virus epitopes, as well as kits containing them, compositions containing them, and passive vaccines comprising them, in one embodiment, the antibody or antigen binding fragment thereof is capable of binding to a whole dengue virus particle better than binding to a dengue virus surface glycoprotein. Also disclosed are methods of using the antibodies or antigen binding fragments thereof, nucleic acids encoding them, vectors expressing the nucleic acids, host producing them, and methods of manufacturing them. |
申请公布号 |
WO2016148653(A1) |
申请公布日期 |
2016.09.22 |
申请号 |
WO2016SG50124 |
申请日期 |
2016.03.17 |
申请人 |
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH;NATIONAL UNIVERSITY OF SINGAPORE |
发明人 |
WANG, Cheng-I;FINK, Katja;MACARY, Paul;ZUEST, Roland;XU, Meihui |
分类号 |
C07K16/10;A61K39/42;A61P31/12;G01N33/569 |
主分类号 |
C07K16/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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