| 摘要 |
Corticosteroids of the formulae …<CHEM>… wherein:… R<1><6> is methyl; and… R<1><7> independently is hydrogen, or C2 to C6 linear or branched acyl or R<1><6> and OR<1><7> taken together are the radical (IV) …<CHEM>… where R<3> is hydrogen, C1 to C6 linear or branched alkyl, and R<4> is the same or different than R<3> as defined above or is C1 to C6 linear or branched alkoxy or R<3> and R<4> taken together with the carbon atom of said radical is C4 to C9 heterocyclic alkyl having one heterocyclic atom that is oxygen, R<2><1> independently is C1 to C6 linear or branched alkyl or C4 to C9 heterocyclic alkyl having one heterocyclic atom that is oxygen; or OR<1><7> and OR<2><1> taken together are the radical (IV) where R<3> is defined above and R<4> is C1 to C6 linear or branched alkoxy; Y is selected from the group methyl, halomethyl, and the radical -CH2OC(O)R where R is C2 to C6 linear or branched alkyl; Z independently is C1 to C7 linear or branched acyloxy, hydroxy or halo or Z and OR<1><7> taken together are the radical (IV) where R<3> and R<4> is defined above; are useful as anti-inflammatory agents. Compounds III can be prepared from compounds I through compounds II. |
