Antinematodal methods and compositions

摘要

There are provided methods and compositions useful in cell-cell fusion using Fusion Family (FF) proteins of nematode origin. There are further provided antinematodal methods and compositions, utilizing fusogenic proteins of the nematode Fusion Family.

主权项

1. A method for fusing a first mammalian cell and a second mammalian cell; comprising:
(i) incubating a first mammalian cell expressing a nematode fusogenic protein with a second mammalian cell expressing a nematode fusogenic protein; and (ii) fusing the first and second mammalian cells, wherein the nematode fusogenic protein is selected from the group consisting of anchor-cell fusion failure 1 (AFF-1) and epithelial fusion failure 1 (EFF-1) and wherein the first and second mammalian cells are of the same species.