| 摘要 |
NEW MATERIAL:2-Aceyl-6-aminomethylphenol derivatives of fomula I [R<1> is alkyl, H, CnH2n-R<7> (n is 0, 1-6; R<7> is cycloalkl, phenyl, alkoxy, alkylthio);R<2> is alkyl, cycloalkyl, phenyl; R<3>, R<4> are H, R<2> along with R<3> or R<2> along with R<4> form alkylene; R<5> is H, alkyl; R<6> is H, alkyl, acyl]. EXAMPLE:2-Acetyl-4-tert.-butyl-6-aminomethylphenol. USE:Anti-inflammatory agent; It is freed from the side effect of gastric ulcer and has anti-inflammatory, analgesic, antipyretic, diuretic and hypotensive activities, thus being effective on the treatment and prevention of diseases caused by inflammation, edema and hypertension. PREPARATION:For example, A compound of formula II (R<10> is acyl) is subjected to the elimination reaction of the R<10> group to form the compound of formula I where R<6> is H.
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