发明名称 |
HUMANISED ANTIBODIES WITH ANTI-TUMOUR ACTIVITY |
摘要 |
The present invention provides humanised antibodies and binding domains thereof with anti-tumour activity. In particular the humanised antibodies have specific binding to and direct killing of human colon tumour cells and display potent immune-mediated cytotoxic activity against human colon cancer cells in vitro using antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) assays and in vivo using mouse tumour models. |
申请公布号 |
EA024695(B1) |
申请公布日期 |
2016.10.31 |
申请号 |
EA20110071133 |
申请日期 |
2010.03.16 |
申请人 |
CEPHALON AUSTRALIA PTY LTD |
发明人 |
KIENZLE Norbert, Alexander;CLARKE Adam, William;DOYLE Anthony, Gerard;JENNINGS Philip, Anthony;POLLARD Matthew |
分类号 |
C07K16/30;A61K39/395;A61P35/00 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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