| 主权项 |
1. A pharmaceutical composition comprising: (a) at least one antibacterial agent or a pharmaceutically acceptable derivative thereof; and (b) a compound of Formula (I)or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein:
Q is a heteroaryl selected from oxadiazole, thiadiazole and tetrazole; R1 is:
(a) hydrogen,(b) (CO)n—R3, or(c) COOR4, n is 0 or 1; R2 is:
(a) SO3M M is hydrogen or a cation; R3 is:
(a) hydrogen,(b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, OR5, CN, COOR5, CONR5R7, NR6R7, NR5COR8, NR5CONR6R7, heterocyclyl, heteroaryl, cycloalkyl and aryl,(c) NR6R7,(d) CONR6R7,(e) aryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, and NHCONR6R7,(f) heterocyclyl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, and NHCONR6R7,(g) heteroaryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, and NHCONR6R7, or(h) OR8; R4 is:
(a) hydrogen, or(b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, OR5, CN, COOR5, CONR6R7, NR6R7, NR5COR8, heterocyclyl, heteroaryl, cycloalkyl and aryl; R5 and R8 are each independently:
(a) hydrogen, or(b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, CN, CONR6R7, NR6R7, heterocyclyl, heteroaryl, cycloalkyl and aryl; R6 and R7 are each independently:
(a) hydrogen, or(b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, OR5, CN, COOR5, CONR5R8, NR5R8, NR5COR8, heterocyclyl, heteroaryl, cycloalkyl and aryl. |
