| 发明名称 |
Neprilysin inhibitors |
| 摘要 |
In one aspect, the invention relates to compounds having the formula:;
where R1, R2, R3, X, R4, R5, and R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds. |
| 申请公布号 |
US9499487(B2) |
申请公布日期 |
2016.11.22 |
| 申请号 |
US201213475076 |
申请日期 |
2012.05.18 |
| 申请人 |
Theravance Biopharma R&D IP, LLC |
发明人 |
Fleury Melissa;Gendron Roland;Hughes Adam D.;Schmidt Jane |
| 分类号 |
A61K31/565;A61K31/4418;C07D261/18;A61K31/42;C07D213/81;C07D237/04;C07D237/24;C07D239/28;C07D241/24;C07D249/04;C07D249/10;C07D249/18;C07D263/34;C07D307/68;C07D333/38;C07D401/06;C07D471/04;C07D487/04;C07D498/04 |
主分类号 |
A61K31/565 |
| 代理机构 |
|
代理人 |
Hagenah Jeffrey A.;Petka Wendy |
| 主权项 |
1. A compound of formula I:where:
R2 is OH; R3 is —CF3; R1 is —OR10; R10 is H or —C1-6alkyl; X is pyridyltriazole; R4 is H; R5 is H; and R6 is H. |
| 地址 |
South San Francisco CA US |
