| 主权项 |
1. A method of treating or preventing a disease caused by a parasite of the group of Apicomplexa, comprising administering at least one compound of formula (V)wherein
R1 and R2 are aryl(C1-C4)alkyl, heteroaryl(C1-C4)alkyl or (C1-C4)alkoxyphenyl(C1-C4)alkyl; R3 and R4 are independently selected from OH, OCH3, COOH, and phenylalkyl; or R3 and R4 together with
(i) CO—0 form a 6-membered lactone ring;(ii) O—C(A)(B)—O form a 7-membered acetal or ketal ring; or(iii) O—CH(A)-CH(B)—O or O—(CH2)n—O form a ring with two ether oxygens, n being 1, 2, 3 or 4;wherein A and B are independently selected from hydrogen, (C1-C4)alkyl, and (C1-C4) alkenyl; X1—Y1—Z1 and X2—Y2—Z2 are independently selected from CH2—CO—O, NH—CNH—NH, CH2—CO—NH, CH2—CNH—O, CH2—CNH—NH and CH2—CO; and R5, R6, R7, R8, R9 and R10 are H; wherein the aryl and heteroaryl moieties comprise one or two rings, each ring containing 5 or 6 atoms and wherein heteroaryl moieties comprise at least one heteroatom selected from N, 0, and S. |
