发明名称 |
TETRAPEPTIDES, METHODS FOR THEIR PREPARATION AND THEIR USE IN ANALGESIC COMPOSITIONS |
摘要 |
<p>Compounds of the formula <IMAGE> and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D, when applicable, define the chirality; R1 and R2 independently are hydrogen or C1-C3 primary alkyl; R3 is C1-C4 primary or secondary alkyl or -CH2CH2-S-CH3; R4 is hydrogen or C1-C3 primary alkyl; R5 is hydrogen or C1-C3 primary alkyl; Y is hydrogen or acetyl; and Z is <IMAGE> -CH2OH, or -CN; subject to the limitation that no more than one of R4 and R5 is C1-C3 primary alkyl; are useful analgesic agents.</p> |
申请公布号 |
EP0001684(B1) |
申请公布日期 |
1981.09.02 |
申请号 |
EP19780300420 |
申请日期 |
1978.09.27 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
SMITHWICK, EDWARD LEE, JR;FREDERICKSON, ROBERT CURTIS ARTHUR;SHUMAN, ROBERT THEODORE |
分类号 |
C07K5/08;A61K38/07;A61K38/22;C07K1/113;C07K5/087;C07K5/10;C07K5/107;C07K14/575;C07K14/655;(IPC1-7):07C103/52 |
主分类号 |
C07K5/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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