发明名称 |
PROCESS FOR PRODUCING 2,4-DIAMINO-5-BENZYL-PYRIMIDINE DERIVATIVES |
摘要 |
Benzyl cyanoacetals of formula: <IMAGE> wherein R1, R2 and R3 are the same or different and each is a halogen or a hydrogen atom, an alkoxy group, an alkyl group, or a dialkylamino group; R4 is an alkoxycarbonyl group, or an aldehyde group; AND R5 is an alkyl group; the alkyl or alkoxy groups each having from 1 to 4 carbon atoms, and their use as intermediates in the preparation of antibacterial 2,4-diamino-5-benzylpyrimidines. They are prepared from a reaction between an orthoester and an alpha -substituted- beta -benzylpropionitrile and then the resulting cyanoacetal is converted to the benzyl-pyrimidine by reaction with guanidine. |
申请公布号 |
HU178138(B) |
申请公布日期 |
1982.03.28 |
申请号 |
HU1977WE00602 |
申请日期 |
1977.06.08 |
申请人 |
THE WELLICOME FOUNDATION LTD,GB |
发明人 |
YEOWELL,DAVID,A.,US;SWARINGEN,ROY,A.,US |
分类号 |
A01G5/04;C07C43/30;C07C67/00;C07C67/27;C07C253/00;C07C255/32;C07C255/37;C07C255/40;C07C255/41;C07C255/43;C07C255/53;C07C255/56;C07C255/58;C07D239/48;C07D239/49 |
主分类号 |
A01G5/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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