BRIDGED CATHARANTHUS ALKALOID DIMERS

摘要

X-4956 Novel bridged vinca dimers in which two indole-dihydroindole C-3 carboxamides are linked through the nitrogen atom of a carboxamide group are described herein. These compounds are prepared by reacting the corresponding azide of an indoledihydroindole alkaloid with an appropriate diamine or triamine. The compounds are useful as oncolytic agents.