| 摘要 |
<p>Described herein are novel amino-substituted-4,5,6,7-tetrahydro-1H (or 2H)-indazoles of the formulae I II wherein one of R and R1 is H and the other is N(R2)2; where each R2 is individually allyl, methyl, ethyl or n-propyl; and pharmaceutically-acceptable acid addition salts thereof. These compounds are useful as prolactin inhibitors and in the treatment of Parkinson's Syndrome. They are prepared by reacting, by reductive alkylation with an aldehyde or by reacting with an alkyl halide or anhydride followed by reduction, an 5 (or 6)-amino-4,5,6,7-tetrahydro-1H (or 2H)-indazole compound of the formulae IB IIB wherein one of R and R1 is H and the other is N(R2)2 where both R2 's are H. Also disclosed are intermediate tautomers of the formulae IX IXa These tautomers are prepared by reacting compounds of the formulae VIII VIIIa wherein R5 is (C1-C3) alkyl or benzyl, with acid hydrolysis.</p> |
