RECOMBINANT VECTORS EXPRESSING MUCIN AND CARCINOEMBRYOINIC ANTIGEN

摘要

The invention is directed to a pharmaceutical composition and use thereof for inducing an immunological response against a cell expressing a breast cancer associated antigen in a human having breast cancer or at risk for developing such a breast cancer tumor comprising (a) a first vector containing one or more DNA segments that encode (i) mucin (MUC) or an antigenic portion thereof or modified version thereof and (ii) carcinoembryonic antigen (CEA) or an antigenic portion thereof or modified version thereof, and (b) at least a second vector containing one or more DNA segments that encode (i) MUC or antigenic portion thereof or modified version thereof and (ii) CEA or an antigenic portion thereof or modified version thereof, wherein the second vector is for administration to the human at regular intervals after the administration of the first vector.