| 发明名称 | Thrombin-binding antibody molecules | ||
| 摘要 | This invention relates to isolated antibodies which recognize the exosite 1 epitope of thrombin and selectively inhibit thrombin without promoting bleeding. These antibody molecules may be useful in the treatment and prevention of thrombosis, embolism and other conditions mediated by thrombin. | ||
| 申请公布号 | US9518128(B2) | 申请公布日期 | 2016.12.13 |
| 申请号 | US201414309403 | 申请日期 | 2014.06.19 |
| 申请人 | Janssen Pharmaceuticals, Inc. | 发明人 | Huntington James Andrew;Baglin Trevor;Langdown Jonathan |
| 分类号 | A61K39/395;C07K16/36;A61K39/00 | 主分类号 | A61K39/395 |
| 代理机构 | Stradley Ronon Stevens & Young, LLP | 代理人 | Stradley Ronon Stevens & Young, LLP |
| 主权项 | 1. An isolated or recombinant antibody molecule that specifically binds to the exosite 1 region of thrombin, comprising an LCDR1 having the amino acid sequence of SEQ ID NO: 15, an LCDR2 having the amino acid sequence of SEQ ID NO: 8, and an LCDR3 having the amino acid sequence of SEQ ID NO: 9, and comprising an HCDR1 having the amino acid sequence of SEQ ID NO: 3, an HCDR2 having the amino acid sequence of SEQ ID NO: 4, and an HCDR3 having the amino acid sequence of SEQ ID NO: 5. | ||
| 地址 | Titusville NJ US | ||