| 发明名称 | A4B7 peptide monomer and dimer antagonists | ||
| 摘要 | The invention relates to peptide dimer compounds and peptide monomer compounds that potently inhibit binding of α4β7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo, possess high selectivity against α4β1 binding, and have high stability under gastrointestinal conditions. | ||
| 申请公布号 | US9518091(B2) | 申请公布日期 | 2016.12.13 |
| 申请号 | US201615046325 | 申请日期 | 2016.02.17 |
| 申请人 | Protagonist Therapeutics, Inc. | 发明人 | Bhandari Ashok;Patel Dinesh V.;Zemede Genet;Mattheakis Larry C.;Liu David |
| 分类号 | A61K38/00;C07K2/00;C07K4/00;C07K5/00;C07K7/00;C07K14/00;C07K16/00;C07K17/00;C07K7/08;C07K7/06;C07K14/725 | 主分类号 | A61K38/00 |
| 代理机构 | Cooley LLP | 代理人 | Cooley LLP |
| 主权项 | 1. A peptide comprising the amino acid sequence: Pen-(N-Me-Arg)-Ser-Asp-Thr-Leu-Pen-Phe(4-tBu)-(β-homo-Glu)-(D-Lys). | ||
| 地址 | Milpitas CA US | ||