| 摘要 |
<p>NEW MATERIAL:The compound of formulaI[R is H or methyl; R<1> is (substituted) alkyl or phenyl; R<2> and R<3> are (protected) hydroxyl; when both R<2> and R<3> are protected hydroxyl groups, single protecting group may be shared in both R<2> and R<3>; R<4> is H or (protected) hydroxyl]or of formula II[R<5> is (protected) amino]. EXAMPLE:N<3>-( 1,1-Dimethyl-2, 2, 2-trichloro )ethoxycarbonyl-2'-O-phenoxyacetic acid-3',5'-(tetraisopropyl)disiloxanylene-uridine of formula III. USE:Material for genetic industry. There is no side reaction at the imide group of the base fraction. PROCESS:The objective compound can be prepared by reacting the nucleoside of formula IV or formula V (e.g. uridine) with the alkyl chlorocarbonate of formula VI, (e.g. ethoxycarbonyl chloride) preferably at 0-80 deg.C for 2-24hr.</p> |
