| 摘要 |
Pyridoquinazoline carboxylic acids and amides of formula (I) and their acid addn. salts are new. In (I) one of D and D' is nitrogen, the other is carbon and the dotted represents two additional bonds. R1 and R2 are each H, alkyl, alkoxy, hydroxy or halo. X is oxygen or NR5. R5 is H or a-7C alkyl. R3 is 2-7C alkylene. R4 is 1-7C alkylene. Y is oxygen or sulphur. m and n are zero or 1. A is an opt. substd., aromatic, 5 or 6 membered heterocycle, provided that m and n are both zero when A is bonded via a heterocyclic N atom. (I) are made by reacting the corresp. acid with an amine or alcohol. (I) inhibit substances (e.g. histamine, slow-reacting substance and platelet activating factor) released during allergic reactions and also the enzyme thromboxan synthase. They are useful for treating allergies (hay fever, chronic bronchitis, food allergy etc.) and thrombotic vascular diseases. The usual daily dose is 0.1-1.5g. - |
