| 发明名称 | Stable formulations for lyophilizing therapeutic particles | ||
| 摘要 | The present disclosure generally relates to lyophilized pharmaceutical compositions comprising a sugar, a cyclodextrin, and polymeric nanoparticles comprising a copolymer and a therapeutic agent which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles. | ||
| 申请公布号 | US9498443(B2) | 申请公布日期 | 2016.11.22 |
| 申请号 | US201414535713 | 申请日期 | 2014.11.07 |
| 申请人 | Pfizer Inc. | 发明人 | Troiano Greg;Song Young-Ho;Zale Stephen E.;Wright James;Van Geen Hoven Christina |
| 分类号 | A61K31/335;A61K31/337;A61K47/26;A61K47/34;A61K47/40;A61K9/16;A61K9/19;A61K9/00;A61K9/51 | 主分类号 | A61K31/335 |
| 代理机构 | Goodwin Proctor LLP | 代理人 | Goodwin Proctor LLP |
| 主权项 | 1. A lyophilized pharmaceutical composition comprising: polymeric nanoparticles comprising: a poly(lactic) acid-block-poly(ethylene)glycol copolymer or poly(lactic)-co-poly(glycolic) acid-block-poly(ethylene)glycol copolymer, and a therapeutic agent; a sugar; and hydroxypropyl β-cyclodextrin, wherein upon reconstitution of the lyophilized pharmaceutical composition in an aqueous medium, the composition comprises 4 to 6 weight percent of the sugar; and 7 to 12 weight percent of the hydroxypropyl β-cyclodextrin. | ||
| 地址 | New York NY US | ||