Testosterone solutions for the treatment of testosterone deficiency

摘要

Solutions of testosterone for oromucosal administration providing an increase in serum testosterone levels in subjects deficient in endogenous testosterone levels, and therapeutic methods for providing an increase in serum testosterone levels and methods for treating a disease or a symptom associated with deficient endogenous levels of testosterone.

主权项

1. A method of treating testosterone deficiency in a male subject in need thereof, the method comprising administering oromucosally to the subject a dose of 10 to 500 microliters of a non-aqueous testosterone solution comprising 100 to 1000 micrograms of testosterone, 10 to 25% (v/v) ethanol, and 90 to 75% (v/v) of a pharmaceutically acceptable ester of a C8-22 fatty acid and a C2-6 alcohol, and administering to the subject between two and ten doses per day, wherein said dose is administered in the form of a spray, drops or by a dosage pen.