2-AZASPIRO(4.(3+N))-3-CARBOXYLIC ACID DERIVATIVES,A PROCESS FOR THEIR PREPARATION,AGENTS CONTAINING THESE DERIVATIVES AND THEIR USE

摘要

The invention relates to compounds of the formula I (I) in which n denotes 1, 2, 3 or 4, R is alkyl, alkenyl cycloalkyl, aryl, optionally mono-, di- oder trisubstituted by alkyl, alkoxy, hydroxy, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or indol-3-yl, R1 denotes an optionally protected radical of a naturally occurring amino acid HOOC-CH(NH2)-R1, R2 denotes hydrogen, alkyl or optionally nitro-substituted aralkyl, R3 denotes hydrogen, alkyl or cycloalkyl or optionally nitro-substituted aralkyl and X denotes 2 hydrogen atoms or 1 oxygen atom, their physiologically tolerated salts with acids and, if R2 and/or R3 denote hydrogen, with bases, a process for their preparation, agents containing these derivatives and their use as medicaments.