| 摘要 |
PURPOSE:To prepare the titled compound useful as a preparation raw material of pharmaceuticals, etc., in shortened reaction time, in high yield, by adding potassium hydroxide to a specific mixed solvent and hydrolyzing 3,4-dichlorobenzotrifluoride in the solution keeping the reaction temperature at a preset level. CONSTITUTION:Potassium hydroxide is added to a mixed solvent comprising an inert aprotic solvent and an aliphatic tertiary alcohol, and the mixture is maintained at 100-130 deg.C. 3,4-Dichlorobenzotrifluoride is added to the above mixed solvent and made to react for 0.5-4hr to effect the hydrolysis and obtain the objective 2-chloro-4-trifluoromethylphenol in a yield of >=90%. The inert aprotic solvent is preferably dimethylsulfoxide (DMSO) or hexamethylphosphoramide, especially DMSO. The aliphatic alcohol is e.g. t-butanol, pinacol, 2,5- dimethylhexane-2,5-diol, etc. |
